組長的話
這是方便IELTS讀書會會員的天地,每人每天應該將自己看到聽到值得分享的東西,放上來與大家分享喔!!! 本讀書會成員有Louis,Barry,Oska,Lillian,Gobby,Mavis,Lica

紅色標示的字好像是特殊的藥名或化學專有名詞 不了解是什麼意思

 

A combination of two inexpensive existing drugs may offer a new way to treat breast cancer, according to UK and Finnish researchers. 

The common chemotherapy drug and a brittle bone medicine almost completely stopped the growth of tumours in mice. 

The Journal of the National Cancer Institute said the combination cost a twentieth of Herceptin, given to breast cancer patients by the NHS. 

Specialists said the results of human trials now under way would be crucial.

In the UK, almost 46,000 new cases of breast cancer are diagnosed each year.

Although modern treatments mean that cases caught sufficiently early, some via breast screening programmes, have an excellent chance of being successfully treated.

The study was a joint project between researchers at the University of Sheffield and the Kuopio University in Finland

Its findings could offer an even more effective way to help some patients.

It used a dose of the drug doxorubicin, a common component of chemotherapy regimes, followed 24 hours later by zoledronic acid, currently given to osteoporosis patients. 

In the mice, this stopped 99.99% of new cancer cell growth in tumours.

It is thought the first drug could be "priming" the tumour to be more sensitive to the cancer-cell killing qualities of the second drug. 

Dr Ingunn Holen, who led the study, said that the study showed that the drug cocktail could "kill breast tumours".

"These results show that a patient may benefit the most if these two drugs are given in this particular order."

She said that the results of a human trial were expected later this year. 

Speed advantage

If that proves successful, the drugs would not have to undergo a lengthy licensing process, simply have the change of use included in their current licence. 

Breast Cancer Campaign, the charity which funded the study, said it was encouraged by the potential for the drug to be made swiftly available to women. 

Its chief executive, Pamela Goldberg, said: "The results of this study could change the way breast cancer patients are treated. 

"The good news is the that the two treatments are relatively inexpensive and already used in the clinic." 

A spokesman for Cancer Research UK said that a study in humans would be important.

"Establishing the most effective combinations of drug treatments and the timings in which they are given is an important area of clinical research. 

"But the benefits of giving zoledronic acid after doxorubicin have only been shown here in mice and now need to be evaluated more fully in people with breast cancer."

 

Chemotherapy 化學療法

Brittle 易碎的

Tumours  腫瘤

Twentieth 第二十的

Trial 試驗, 試用

under way 在進行中

crucial 決定性的, 重要的

regime 政體,政權,統治方式

osteoporosis 骨質疏鬆

sensitive to 敏感,易感覺的

cocktail 混合物,雞尾酒

swiftly 迅速地,敏捷地

chief executive 州長,政府最高首長

timing 時間的選擇或安排

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  • digibravo
  • 幫妳查了,但看看知道他是制什麼病就好囉。
    藥理: 唑來磷酸(Zoledronic acid)是雙磷酸鹽化合物,主要作用在骨骼,抑制蝕骨細胞(osteoclast) 活性,減少鈣質從骨骼中釋放。
    Doxorubicin(小紅莓)是一種廣泛使用及對多種癌症均有治療效果的抗癌藥物,尤其在乳癌治療中常是不可或缺且效果佳。
    Priming醫學辭典解釋
    Definition: Priming refers to a increased sensitivity to certain stimuli due to prior experience. Because priming it believed to occur outside of conscious awareness, it is different from memory that relies on the direct retrieval of information. Direct retrieval utilizes explicit memory, while priming relies on implicit memory. Research has also shown that the affects of priming can impact the decision-making process (Jacoby, 1983).
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